Pioneering diagnostics

Biomarkers

Cancer

Overexpression of the Transcription Factor Sp1 Activates the OAS-RNAse L-RIG-I Pathway
Dupuis-Maurin V, Brinza L, Baguet J, Plantamura E, Schicklin S, Chambion S, Macari C, Tomkowiak M, Deniaud E, Leverrier Y, Marvel J, Michallet MC.
PloS One 2015

Identification and Validation of a Two-Gene Expression Index for Subtype Classification and Prognosis in Diffuse Large B-Cell Lymphoma
Xu Q, Tan C, Ni S, Wang Q, Wu F, Liu F, Ye X, Meng X, Sheng W, Du X.
Scientific Reports 2015

Identification and Validation of Long Noncoding RNA Biomarkers in Human Non-Small-Cell Lung Carcinomas
Yu H, Xu Q, Liu F, Ye X, Wang J, Meng X.
Journal of Thoracic Oncology 2015

Prostate Cancer Biomarker Annexin A3 Detected in Urines Obtained Following Digital Rectal Examination Presents Antigenic Variability
Hamelin-Peyron C., Vlaeminck-Guillem V., Haidous H., Schwall G.P., Poznanovic S., Gorius-Gallet E., Michel S., Larue A., Guillotte M., Ruffion A., Choquet-Kastylevsky G., Ataman-Onal Y.
Clinical Biochemistry 2014

Development of Monoclonal Antibodies to Human Kallikrein-Related Peptidase 6 (KLK6) and Their Use in an Immunofluorometric Assay for Free KLK6
Ott C., Ainciburu M., Parent C., Michel S., Roesch C., Vourc'h P., Corcia P., Heuze-Vourc'h N., Jolivet-Reynaud C., Courty Y.
Biological Chemistry 2014

MicroRNA-202-3p Inhibits Cell Proliferation by Targeting ADP-Ribosylation Factor-Like 5A in Human Colorectal Carcinoma
Wang Q., Huang Z., Guo W., Ni S., Xiao X., Wang L., Huang D., Tan C., Xu Q., Zha R., Zhang J., Sheng W., He X., Du X.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 2014

Comparison of Hepatic Resection and Radiofrequency Ablation for Small Hepatocellular Carcinoma: a Meta-Analysis of 16,103 Patients
Xu Q., Kobayashi S., Ye X., Meng X.
Scientific Reports 2014

The Effect of Colonoscopy on Whole Blood Gene Expression Profile: an Experimental Investigation for Colorectal Cancer Biomarker Discovery
Xu Y., Xu Q., Yang L., Liu F., Ye X., Wu F., Ni S., Tan C., Cai G., Meng X., Cai S., Du X.
Journal of Cancer Research and Clinical Oncology 2014

Microarray-Based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer.
Perot P., Cheynet V., Decaussin-Petrucci M., Oriol G., Mugnier N., Rodriguez-Lafrasse C., Ruffion A., Mallet F.
Journal of Visualized Experiments 2013

Gene Expression Analysis of Peripheral Blood Cells Reveals Toll-Like Receptor Pathway Deregulation in Colorectal Cancer.
Xu Y., Xu Q., Yang L., Liu F., Ye X., Wu F., Ni S., Tan C., Cai G., Meng X., Cai S., Du X.
PloS One 2013

Identification and Validation of a Blood-Based 18-Gene Expression Signature in Colorectal Cancer.
Xu Y., Xu Q., Yang L., Ye X., Liu F., Wu F., Ni S., Tan C., Cai G., Meng X., Cai S., Du X.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 2013

Characterization of Three Amino-Functionalized Surfaces and Evaluation of Antibody Immobilization for the Multiplex Detection of Tumor Markers Involved in Colorectal Cancer.
Yang Z., Chevolot Y., Gehin T., Dugas V., Xanthopoulos N., Laporte V., Delair T., Ataman-Onal Y., Choquet-Kastylevsky G., Souteyrand E., Laurenceau E.
Langmuir : the ACS Journal of Surfaces and Colloids 2013

92-Gene Molecular Profiling in Identification of Cancer Origin: A Retrospective Study in Chinese Population and Performance Within Different Subgroups.
Wu F, Huang D, Wang L, Xu Q, Liu F, Ye X, Meng X, Du X.
PLoS One 2012

Cancer Biomarkers Detection Using 3D Microstructured Protein Chip: Implementation of Customized Multiplex Immunoassay.
Yang Z, Chevolot Y, Ataman-Onal Y, Choquet-Kastylevsky G, Souteyrand E, Laurenceau E.
Sensors and Actuators B: Chemical 2012

Pro-Nerve Growth Factor Induces Autocrine Stimulation of Breast Cancer Cell Invasion Through Tropomyosin-Related Kinase A (TrkA) and Sortilin Protein.
Demont Y, Corbet C, Page A, Ataman-Onal Y, Choquet-Kastylevsky G, Fliniaux I, Le Bourhis X, Toillon RA, Bradshaw RA, Hondermarck H.
Journal of Biological Chemistry 2012

Sepsis

Marked Alterations of Neutrophil Functions During Sepsis-Induced Immunosuppression
Demaret J, Venet F, Friggeri A, Cazalis MA, Plassais J, Jallades L, Malcus C, Poitevin-Later F, Textoris J, Lepape A, Monneret G.
Journal of Leukocyte Biology 2015

Altered T Lymphocyte Proliferation Upon Lipopolysaccharide Challenge Ex Vivo
Poujol F, Monneret G, Pachot A, Textoris J, Venet F.
PloS One 2015

Low-Dose Hydrocortisone Reduces Norepinephrine Duration in Severe Burn Patients: a Randomized Clinical Trial
Venet F, Plassais J, Textoris J, Cazalis MA, Pachot A, Bertin-Maghit M, Magnin C, Rimmele T, Monneret G, Tissot S.
Critical Care 2015

Early and Dynamic Changes in Gene Expression in Septic Shock Patients: a Genome-Wide Approach
Cazalis M.-A., Lepape A., Venet F., Frager F., Mougin B., Vallin H., Paye M., Pachot A., Monneret G.
Intensive Care Medicine Experimental 2014

Interferon-Gamma As Adjunctive Immunotherapy for Invasive Fungal Infections: a Case Series
Delsing C.E., Gresnigt M.S., Leentjens J., Preijers F., Frager F.A., Kox M., Monneret G., Venet F., Bleeker-Rovers C.P., van de Veerdonk F.L., Pickkers P., Pachot A., Kullberg B.J., Netea M.G.
BMC Infectious Diseases 2014

Elevated Plasmatic Level of Soluble IL-7 Receptor Is Associated With Increased Mortality in Septic Shock Patients
Demaret J., Villars-Mechin A., Lepape A., Plassais J., Vallin H., Malcus C., Poitevin-Later F., Monneret G., Venet F.
Intensive Care Medicine 2014

S100A8/A9 MRNA Induction in an Ex Vivo Model of Endotoxin Tolerance: Roles of IL-10 and IFNgamma
Fontaine M., Planel S., Peronnet E., Turrel-Davin F., Piriou V., Pachot A., Monneret G., Lepape A., Venet F.
PloS One 2014

Phenotypic Diversity and Emerging New Tools to Study Macrophage Activation in Bacterial Infectious Diseases
Ka M.B., Daumas A., Textoris J., Mege J.L.
Frontiers in Immunology 2014

CD24-Triggered Caspase-Dependent Apoptosis Via Mitochondrial Membrane Depolarization and Reactive Oxygen Species Production of Human Neutrophils Is Impaired in Sepsis
Parlato M., Souza-Fonseca-Guimaraes F., Philippart F., Misset B., Adib-Conquy M., Cavaillon J.M., Captain Study Group.
Journal of Immunology 2014

Flow Cytometric Evaluation of Lymphocyte Transformation Test Based on 5-Ethynyl-2'Deoxyuridine Incorporation As a Clinical Alternative to Tritiated Thymidine Uptake Measurement
Poujol F., Monneret G., Friggeri A., Rimmele T., Malcus C., Poitevin-Later F., Pachot A., Lepape A., Textoris J., Venet F.
Journal of Immunological Methods 2014

The Discriminative Capacity of Soluble Toll-Like Receptor (STLR)2 and STLR4 in Inflammatory Diseases
Ten Oever J., Kox M., van de Veerdonk F.L., Mothapo K.M., Slavcovici A., Jansen T.L., Tweehuysen L., Giamarellos-Bourboulis E.J., Schneeberger P.M., Wever P.C., Stoffels M., Simon A., van der Meer J., Johnson M.D., Kullberg B.J., Pickkers P., Pachot A., Joosten L., Netea M.G.
BMC Immunology 2014

A Revival for Immunoglobulin Therapy in Septic Shock?
Textoris J., Calandra T., Pene F.
Intensive Care Medicine 2014

Reactivation of Multiple Viruses in Patients With Sepsis
Walton A.H., Muenzer J.T., Rasche D., Boomer J.S., Sato B., Brownstein B.H., Pachot A., Brooks T.L., Deych E., Shannon W.D., Green J.M., Storch G.A., Hotchkiss R.S.
PloS One 2014

Identification of Biomarkers of Response to IFNg During Endotoxin Tolerance: Application to Septic Shock
Allantaz-Frager F., Turrel-Davin F., Venet F., Monnin C., De Saint Jean A., Barbalat V., Cerrato E., Pachot A., Lepape A., Monneret G.
PloS One 2013

Concomitant Assessment of PSP and NT-ProCNP As Predictive Markers of Sepsis in Severe Trauma Patients Under Mechanical Ventilation.
Gouel-Cheron A., Dupin M., Chanteperdix M., Chaillol I., Venet F., Pachot A., Monneret G., Floccard B., Allaouchiche B.
Critical Care (London, England) 2013

Circulating Galectin-3 in Infections and Non-Infectious Inflammatory Diseases.
ten Oever J., Giamarellos-Bourboulis E.J., van de Veerdonk F.L., Stelma F.F., Simon A., Janssen M., Johnson M., Pachot A., Kullberg B.J., Joosten L.A.B., Netea M.G.
European Journal of Clinical Microbiology & Infectious Diseases 2013

Early Interleukin-6 and Slope of Monocyte Human Leukocyte Antigen-DR: a Powerful Association to Predict the Development of Sepsis After Major Trauma.
Gouel-Cheron A, Allaouchiche B, Guignant C, Davin F, Floccard B, Monneret G.
PLoS One 2012

Gene Expression Profiles in Alveolar Macrophages Induced by Lipopolysaccharide in Humans.
Reynier F, De Vos AF, Hoogerwerf JJ, Bresser P, Van Der Zee JS, Paye M, Pachot A, Mougin B, Van Der Poll T.
Molecular Medicine 2012

 

Bacterial infections

Assessment of Terbium (III) As a Luminescent Probe for the Detection of Tuberculosis Biomarkers
Bamogo W, Mugherli L, Banyasz A, Novelli-Rousseau A, Mallard F, Tran-Thi TH.
Analytica Chimica Acta 2015

Granulomatous Response to Coxiella Burnetii, the Agent of Q Fever: the Lessons from Gene Expression Analysis
Faugaret D, Ben AA, Alingrin J, Daumas A, Delaby A, Lepolard C, Raoult D, Textoris J, Mege JL.
Frontiers in Cellular and Infection Microbiology 2014

Viral infections

Differential Proteomic Analysis of Virus-Enriched Fractions Obtained From Plasma Pools of Patients with Dengue Fever or Severe Dengue
Fragnoud R, Flamand M, Reynier F, Buchy P, Duong V, Pachot A, Paranhos-Baccala G, Bedin F.
BMC Infectious Diseases 2015

Comparative Exoproteomics and Host Inflammatory Response in Staphylococcus Aureus Skin and Soft Tissue Infections, Bacteremia, and Subclinical Colonization
Liew YK, Awang HR, van Belkum A, Chong PP, Neela V.
Clinical and Vaccine Immunology 2015

Dengue sévère : des hypothèses de la pathogénicité aux outils de pronostic
Fragnoud R., Paranhos-Baccala G., Bedin F.
Virologie 2014

Isotope Coded Protein Labeling Analysis of Plasma Specimens From Acute Severe Dengue Fever Patients.
Fragnoud R, Yugueros-Marcos J, Pachot A, Bedin F.
Proteome Science 2012

Nonstructural Protein NS1 Immunodominant Epitope Detected Specifically in Dengue Virus Infected Material by a SELDI-TOF/MS Based Assay.
Steidel M, Fragnoud R, Guillotte M, Roesch C, Michel S, Meunier T, Paranhos-Baccala G, Gervasi G, Bedin F.
Journal of Medical Virology 2012

Microarray-Based Sketches of the HERV Transcriptome Landscape.
Perot P, Mugnier N, Montgiraud C, Gimenez J, Jaillard M, Bonnaud B, Mallet F.
PLoS One 2012

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